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Liposomal Encapsulation Helps Deliver Medications More Effectively

By Jody Leach


Nutritional supplements and most medications are meant to target specific physical systems or organs. Intravenous drip and injection are the most effective methods of delivery, transferring necessary chemicals directly to the blood. When swallowed, medications usually face degradation in the acids of the upper digestive tract. Liposomal encapsulation creates a protective barrier, ultimately allowing more complete absorption.

Discoveries leading to this process emerged nearly fifty years ago, and have led to the introduction of more controlled methods of administering medications. It is currently important in treating serious medical conditions such as some forms of cancer, treatment-resistant fungal infections, and degenerative vision conditions commonly associated with old age. Standard drug delivery mechanisms still predominate, but encapsulation is proving equally beneficial.

For a medication to pass through the upper digestive tract without being dissolved, it must be protected by a safe and non-toxic barrier. The substance used to encapsulate these drugs is an organic material that closely mimics human cellular walls, making it safer to ingest. After it has been activated by using one of three common processes, small bubbles of liposomes are formed around the tiny grains of medication.

They are microscopic, and can easily pass through the stomach into the small intestine where the coating slowly dissolves, allowing the medication to be absorbed. In many cases, this process actually improves the therapeutic impact, and has the additional benefit of producing fewer side effects. Not all types of medicine are adaptable to this delivery system, which is primarily associated with water-soluble substances.

Because it involves fewer undesirable reactions than invasive delivery, there are immediate advantages of using this process. Liposomes are bio-compatible and biodegradable, leaving behind no undesirable toxins. They not only survive the onslaught of digestive acids, but are able to function as small time-release ports within the gut. When potentially toxic drugs must be used to fight cancers, fewer sensitive tissues face unwanted exposure.

While immediately useful in delivering medication, the process does have drawbacks. The cost of production remains high, but will very likely decrease as research into new product uses expands. There have been issues regarding seal leakage, and common oxidation may also reduce effectiveness. The half-lives of certain drugs decrease using this process, and long-term stability may be shortened. Even so, the potential benefits outweigh known negatives.

The past several years witnessed a transition from mainly medical use to include internal delivery of nutritional supplements and even cosmetic substances. Anecdotal evidence abounds regarding the increased effectiveness of administering both vitamins and minerals in this manner. For years Vitamin C has enjoyed an enviable reputation for fighting upper respiratory viral infections, and encapsulated forms are thought to produce even better results.

Although there is currently widespread information available outlining personal production of encapsulated herbs, vitamins and minerals, making medical-quality products is costly and complicated, and is not a panacea for the problems associated with aging. As uses for this drug delivery process continue to grow, consumers will benefit most from its incorporation into health regimens that are already known to be beneficial.




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